Objective To analyze the effect of quality control in the management of cytotoxic drugs in pharmacy intra-venous drug admixture service(PIVAS).Methods From January 2020 to December 2023,20 staff members of PIVAS in Taizhou Hospital of Traditional Chinese Medicine were selected as the research objects.Traditional PIVAS manage-ment was implemented from January 2022 to December 2021,and quality control was implemented from January 2022 to December 2023.The critical thinking ability scores(seeking truth,open mind,analytical ability,systematic ability,self-confidence,thirst for knowledge,maturity),knowledge-attitude-behavior score of cytotoxic drug management(knowledge,attitude,behavior),incidence of errors in cytotoxic drug formulation,incidence of cytotoxic drug over-flow,and total management satisfaction before and after quality control implementation were compared.Results Af-ter the implementation of quality control,the score of critical thinking ability,knowledge,attitude-behavior score of cytotoxic drug management and the total satisfaction rate of management were higher than those before the implemen-tation,and the differences were statistically significant(all P<0.05).After the implementation of quality control,the incidence of cytotoxic drug preparation errors and the incidence of cytotoxic drug overflow were lower than those be-fore the implementation,and the differences were statistically significant(both P<0.05).Conclusion The application of quality control in the management of cytotoxic drugs in PIVAS can further improve the critical thinking ability of staff and the level of knowledge-belief-behavior of cytotoxic drug management,avoid the occurrence of errors in the preparation of cytotoxic drugs and the overflow of cytotoxic drugs,and improve the overall satisfaction rate of manage-ment.