Neurology is abstract,logical,theoretical and exploratory,which brings some difficulties and challenges to teaching.Under the background of new medical science,a new round of scientific and technological revolution and in-dustrial transformation represented by artificial intelligence and big data has arrived.In response to the cultivation of innovative,applied and compound undergraduate talents of clinical medicine,it is of certain significance to explore how to better promote the improvement of students'relevant medical theory and clinical practice ability through mixed teaching,and to realize the formation of"five skills"literacy of medical talents in the new era of neurology,including Taoism,academic,technology,art and benevolence.This paper takes the undergraduate course of cerebral infarction in neurology as an example to carry out mixed teaching reform,including teaching objectives,teaching resources,teaching methods,specific practices,etc.,in order to provide useful reference for the reform of undergraduate courses in neurology.