Objective To analyze the epidemiological characteristics and annual trend of hepatitis B in Tibet Autono-mous Region from 2018 to 2023,and to further analyze the characteristics of regional and age groups.In order to pro-vide reference for the prevention and control of hepatitis B in Tibet Autonomous Region.Methods The information of new cases of hepatitis B in the medical laboratory of the Tibet Autonomous Region Center for Disease Control and Pre-vention from 2018 to 2023 was collected and analyzed by statistical description.The main observation indicators were the number of cases and the incidence rate,and the trend of annual incidence was analyzed.Results A total of 23 287 patients with hepatitis B were reported in Tibet Autonomous Region from 2018 to 2023,including 1 611 cases of acute hepatitis B(7.86%),15 249 cases of chronic hepatitis B(72.82%)and 3 474 cases of unclassified hepatitis B(16.35%).20~40 is the high incidence age of hepatitis B.The prevalence of hepatitis B was the highest in Changdu and Naqu,which were 177.35/100 000 and 106.53/100 000,respectively.Conclusion The quality control of hepatitis B surveillance should be further strengthened in Tibet,and the role of infectious disease prevention should be given full play to reduce the prevalence of such infectious diseases.