A Causal Analysis of Hypothyroidism and Nonalcoholic Fatty Liver Disease based on Mendelian Randomization
Objectives To explore the causal relationship between hypothyroidism and nonalcoholic fatty liver disease(NAFLD)by two-sample Mendelian randomization.Methods Genome-wide association study(GWAS)data was used to identify genetic variation data associated with hypothyroidism as instrumental variables(IVs).MR-Egger regression,inverse variance weighting method(IVW)and weighted median method(WME)were used to examine the causal effects between hypothyroidism and NAFLD.The causal association was evaluated with OR.Results A total of 334 SNP loci were included as Ⅳ,and there was no heterogeneity and pleiotropy in the Ivs.Based on IVW estimation mryhod,the OR with 95%CI of two different sets were 21.30(95%CI:93.61～125.50)]and 5.79(95%CI:1.03～32.47),which both indicated a significant causal association between the hypothyroidism and NAFLD(P＜0.05).What′s more,the results of Mendelian randomization were robust.Conclusion Hypothyroidism is potentially associated with NAFLD.
NETL
NSTL
万方数据
