基于孟德尔随机化的甲状腺功能减退症与非酒精性脂肪性肝病的因果分析
A Causal Analysis of Hypothyroidism and Nonalcoholic Fatty Liver Disease based on Mendelian Randomization
王冬冬 1高梦瑶 2穆华夏 2卜伟晓 2王蒙 3孔雨佳 2王素珍2
作者信息
- 1. 山东第二医科大学公共卫生学院(261053);中国医科大学公共卫生学院
- 2. 山东第二医科大学公共卫生学院(261053)
- 3. 山东第二医科大学附属医院肝胆外科
- 折叠
摘要
目的 通过两样本孟德尔随机化方法探索甲状腺功能减退和非酒精性脂肪性肝病(NAFLD)之间的因果关系.方法 利用全基因组关联研究数据,确定与甲状腺功能减退相关遗传变异数据为工具变量(Ⅳ),使用MR-Egger回归、逆方差加权法(IVW)和加权中位数法(WME)检验甲状腺功能减退和非酒精性脂肪性肝病之间的因果效应,用OR对因果关系进行评价.结果 研究共纳入 334 个SNP位点作为工具变量,工具变量不存在异质性和多效性.IVW估计中,基于两个数据集分别得到暴露的OR值OR(95%CI):21.30(3.61～125.50)]和OR(95%CI):5.79(1.03～32.47)],均表明甲状腺功能减退与NAFLD之间存在显著的因果关联(P＜0.05),且孟德尔随机化结果稳健.结论 甲状腺功能减退与NAFLD之间存在潜在的因果关系.
Abstract
Objectives To explore the causal relationship between hypothyroidism and nonalcoholic fatty liver disease(NAFLD)by two-sample Mendelian randomization.Methods Genome-wide association study(GWAS)data was used to identify genetic variation data associated with hypothyroidism as instrumental variables(IVs).MR-Egger regression,inverse variance weighting method(IVW)and weighted median method(WME)were used to examine the causal effects between hypothyroidism and NAFLD.The causal association was evaluated with OR.Results A total of 334 SNP loci were included as Ⅳ,and there was no heterogeneity and pleiotropy in the Ivs.Based on IVW estimation mryhod,the OR with 95%CI of two different sets were 21.30(95%CI:93.61～125.50)]and 5.79(95%CI:1.03～32.47),which both indicated a significant causal association between the hypothyroidism and NAFLD(P＜0.05).What′s more,the results of Mendelian randomization were robust.Conclusion Hypothyroidism is potentially associated with NAFLD.
关键词
甲状腺功能减退/非酒精性脂肪性肝病/孟德尔随机化/因果关系Key words
Hypothyroidism/Nonalcoholic fatty liver disease/Mendelian randomization/Causality引用本文复制引用
基金项目
国家自然科学基金项目(82003560)
山东省自然科学基金项目(ZR2020MH340)
山东省自然科学基金项目(ZR2023MH313)
山东省本科教学改革研究项目(M2021174)
山东省本科教学改革研究项目(M2021327)
出版年
2024
NETL
NSTL
万方数据