Objective:To investigate the value of effective hepatic blood flow in predicting the occurrence of liver insufficiency after operation of hepatocellular carcinoma(HCC).Methods:The 15-minute clearance of Indocyanine Green(ICGR15)and EHBFwere measured in 123 patients with hepatocellular carcinoma(HCC)after hepatectomy.To compare the difference of ICGR15 and EHBF in different groups of liver function recovery and the incidence of postoperative liver function insufficiency in different groups of ICG R15 and EHBF.The diagnostic value of ICG R15 and EHBF was compared by receiver operating characteristic(ROC)curve.Results:Of the 123 patients,41(33.3％)developed liver insufficiency after operation.The average values of ICG R15 and EHBF in patients with good liver function were(8.95±7.18)％and(1.01±0.37)min,respectively,while those in patients with liver insufficiency were(15.88±11.55)％and(0.75±0.28)min,respec-tively.The difference was statistically significant(P＜0.05).The incidence of postoperative liver in-sufficiency was 13.0％in EHBF≥1.0 L/min group and 45.5％in＜1.0 L/min group,the difference was statistically significant(P＜0.05).The area under the ICG R15 ROC curve was 0.710(95％CI:0.616-0.804),the critical value was 7.6,the sensitivity was 78.0％,and the specificity was 59.8％.The area under the EHBF ROC curve was 0.718(95％CI:0.624-0.813),the critical value was 0.35,the sensitivity was 73.2％,and the specificity was 70.7％.Conclusion:EHBF can effec-tively predict the occurrence of liver insufficiency after hepatocellular carcinoma operation,and may have the same testing efficacy as ICGR15.
关键词
肝肿瘤/肝储备功能/肝功能不全/肝有效血容量/吲哚菁绿
Key words
Hepatocellular carcinoma/Liver reserve function/Liver insufficiency/Effective he-patic blood flow/Indocyanine green
维普
万方数据