NUF2在乳腺癌中的表达模式及其预后价值
Identification of NUF2 expression pattern and its prognostic value of in breast cancer
刘学智 1朱宝平 1李英德 1陈谦2
作者信息
- 1. 寿光市人民医院 普外科(山东 潍坊 262700)
- 2. 湖北省肿瘤医院 放疗中心(湖北 武汉 430079)
- 折叠
摘要
目的:探究NUF2(Ndc80动粒复合物组分)在乳腺癌(BC)中的表达模式及预后价值.方法:通过ONCOMINE、bc GenExMiner、Kaplan-Meier Plotter和TCGA数据库,分析了 BC患者中 NUF2 的转录水平和预后信息.结果:与正常样品相比,NUF2在BC中高度表达(P＜0.05).年龄≤51岁(P＜0.0001)、淋巴结转移阳性(P=0.0168)、基底样BC(P＜0.0001)、雌激素受体(ER)阴性(P＜0.0001)、孕激素受体(PR)阴性(P＜0.0001)、人表皮生长因子受体-2(HER2)阳性(P＜0.0001)及三阴性(P＜0.0001)的BC患者NUF2表达水平更高.生存分析表明,NUF2表达水平低的BC患者具有更好无复发生存期(RFS,HR=1.63,P＜0.0001).进一步分析显示,NUF2的表达与ER阳性、PR阳性、HER2阴性的BC患者的RFS呈负相关(HR=2.40,P=0.0015).结论:NUF2在BC中发挥重要作用,可以作为ER阳性、PR阳性或HER2阴性BC患者的潜在预后生物标志物.
Abstract
Objective:To investigate the expression pattern and prognostic value of NUF2(Ndc80 kinetochore complex component)in breast cancer(BC).Methods:In the present study,the trancriptional level and survival information of NUF2 was analyzed by ONCOMINE dataset,bc-GenExMiner,Kaplan-Meier Plotter and TCGA.Results:NUF2 was highly expressed in BC com-pared with normal samples(P＜0.05).In addition,the BC patients younger than 51 years old(P＜0.0001),nodal metastasis(P=0.0168),with basal-like BC(P＜0.0001),orestrogen receptor(ER)-negative(P＜0.0001),progesterone receptor(PR)-negative(P＜0.0001),human epidermal growth factor receptor-2(HER2)-positive(P＜0.0001)and triple-negative BC(P＜0.0001)pathological clas-sification have a higher transcriptional level of NUF2.Survival analysis indicated that patients with low expression level of NUF2 have a better relapse-free survival(RFS,HR=1.63,P＜0.0001).Fur-ther anaysis revealed that the NUF2 expression was negatively related to the RFS of BC patients with ER-positive or PR-positive or HER2-negative pathological classification(HR=2.40,P=0.0015).Conclusion:NUF2 play an important role in BC and can be a potential prognostic bio-marker for ER-positive or PR-positive or HER2-negative BC patients.
关键词
乳腺肿瘤/NUF2/预后Key words
Breast cancer/NUF2/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据