Laparoscopic and open surgery for gallbladder cancer:a randomized controlled study
Objective:To explore the effects of different surgical treatment methods on postoperative efficacy,serum inflammatory factors,and T lymphocyte subsets levels in patients with gallbladder cancer. Methods:96 patients with gallbladder cancer admitted to the First Affili-ated Hospital of Xi'an Jiaotong University from January 2020 to March 2023 were randomly divided into a control group and a study group,with 48 patients in each group. The control group under-went open cholecystectomy,while the study group underwent laparoscopic cholecystectomy. The levels of serum inflammatory factors (IL-6,IL-8,CRP,TNF-α),T lymphocyte subsets (CD3+,CD4+,CD8+),perioperative indicators (intestinal function recovery time,surgery time,intraoperative bleeding,hospital stay),incidence of complications,recurrence rate,and mortality rate were com-pared between the two groups before and 7 days after surgery. Results:Before surgery,there was no statistically significant difference in the levels of IL-6,IL-8,CRP,and TNF-α between the two groups(P>0.05);Compared with preoperative levels,the levels of IL-6,IL-8,CRP,and TNF-α in both groups increased 7 days after surgery,and the study group was lower than the control group,with statistical significance(P<0.05). Before surgery,there was no statistically significant difference in CD3+,CD4+,and CD8+between the two groups(P>0.05);Compared with preopera-tive levels,the levels of CD3+,CD4+,and CD8+in both groups decreased 7 days after surgery,and the study group was higher than the control group,with statistical significance(P<0.05);The re-covery time of intestinal function,surgical time,intraoperative blood loss,and hospital stay in the study group were all shorter than those in the control group(P<0.05). The incidence of postopera-tive complications in the study group was lower than that in the control group (2.08％ vs 14.58％),and the difference was statistically significant(P<0.05). There was no statistically significant differ-ence in recurrence and mortality rates between the two groups within one year after surgery(P>0.05).Conclusion:Laparoscopic radical cholecystectomy can significantly improve the levels of inflammatory factors in patients with gallbladder cancer,reduce the risk of postoperative complica-tions,and has high safety.
万方数据
维普
