Diagnostic value of serum hMAM,HER2 and UBE2C for axillary lymph node metastasis of breast cancer
Objective:To explore the diagnostic value of serum human mammaglobin (hMAM),human epidermal growth factor receptor 2 (HER2) and ubiquitin conjugating enzyme 2C (UBE2C) for axillary lymph node metastasis of breast cancer. Methods:Ninety patients with breast cancer admitted to Army 81st Group Hospital from March 2022 to March 2024 were col-lected and separated into metastatic group (n=40) and non-metastatic group (n=50) according to the pathological examination results. General clinical data were collected and analyzed. Multivari-ate logistic regression was used to analyze the influencing factors of axillary lymph node metasta-sis in breast cancer patients. ROC curve was drawn to analyze the diagnostic value of hMAM,HER2,UBE2C for axillary lymph node metastasis in breast cancer patients. Pearson method was applied to analyze the correlation between hMAM,HER2,UBE2C and tumor markers. Results:The proportion of T3+T4 stage and tumor diameter>3 cm in the metastatic group was higher than that in the non-metastatic group (P<0.05). The serum levels of cytokeratin-19 (CK19) and car-cinoembryonic antigen (CEA) in the metastatic group were higher than those in the non-metastatic group (P<0.05). Compared with the non-metastatic group,the serum hMAM,HER2,and UBE2C levels in the metastatic group were greatly increased (P<0.05). Elevated levels of CEA,hMAM,HER2 and UBE2C were all risk factors for axillary lymph node metastasis in breast cancer patients (P<0.05). ROC curve results showed that the AUC predicted by hMAM,HER2,and UBE2C for axillary lymph node metastasis in breast cancer patients was 0.821,0.815,and 0.819,respectively. The AUC of the combination of the three was greatly higher than that of hMAM (Z=2.070,P=0.038),HER2 (Z=2.072,P=0.038),and UBE2C (Z=1.987,P=0.047) diagnosed alone. HMAM,HER2,UBE2C were all positively correlated with tumor detection markers (P<0.05),and the three were also positively correlated with each other (P<0.05). Conclusion:The serum levels of hMAM,HER2 and UBE2C in patients with axillary lymph node metastasis of breast cancer are elevated. The combination of the three has a certain auxiliary predictive value for axillary lymph node metastasis of breast cancer,and may be used as a potential biomarker for axillary lymph node metastasis of breast cancer.
万方数据
维普
