Efficacy of ultrasound-guided ethanol injection combined with microwave ablation for treatment of very large volume benign thyroid nodules
Objective:To compare the efficacy of ultrasound-guided ethanol injection com-bined with microwave ablation (MWA) and MWA alone in the treatment of very large benign thyroid nodules. Methods:83 patients with benign thyroid nodules with volume>30 mL underwent ultrasound-guided thermal ablation were retrospectively analyzed from January 2020 to February 2023 in department of ultrasound,the first medical center of PLA general hospital. The patients were divided into two groups:ethanol injection combined with MWA (EA+MWA) group and MWA group. A comparison was made between the two groups in terms of ablation time,ablation energy,ablation energy per unit volume,nodule volume and reduction rate at 1,3,6 and 12 months post-surgery,symptom score,cosmetic score,thyroid function as well as intraoperative and postopera-tive complications. Results:The mean ablation time[(244.06±226.53)s vs (447.43±197.50)s,P<0.001],ablation energy[(8.15±9.60)kJ vs (15.24±7.61)kJ/mL]and unit volume ablation energy[(0.17±0.19)kJ/mL vs (0.34±0.16)kJ/mL]were significantly lower in EA+MWA group than those in MWA group(P<0.001). The VRR of EA+MWA group was significantly higher than that of MWA group at 6 months and 12 months after operation(P=0.002,P=0.011). Aesthetic and symptom scores were significantly lower in both groups 12 months after surgery(P<0.001). There was no significant change in thyroid function between the two groups during follow-up compared with be-fore treatment(P>0.05),and no serious complications were observed. Conclusion:ethanol in-jection before MWA can shorten the ablation time,reduce the microwave energy,and effectively promote the shrinkage of thyroid nodules.
万方数据
维普
