Objective To explore the clinical effect of Mckissock technique to preserve pedicle fascia to increase the mobility of upper pedicle in reduction mammoplasty of moderate-severe macromastia.Methods The clinical data of 30 macromastia patients performed the reduction mammoplasty with Mckissock technique from January 2019 to October 2022 was analyzed retrospectively.The bilateral vertical bipedicles were designed,pedicle was preserved,fascia layer was thinned,and remaining tissues were freed by inverted T-shape incision.Breast volume was reduced by asymmetrical resection of mammary gland and skin on the inner and outer sides,basal area of breast was reduced,and the appearance of breast was reconstructed.Results The reduction mammoplasty was accomplished successfully in all 30 cases,with operation time of 4.3 to 8.7 hours(mean 6.0± 0.4 hours).The operative incision reached stage I healing in all cases without complications as skin necrosis,fat liquefaction,hematoma or infection.Good blood circulation and sensation was achieved in the nipple areola complex(NAC).During 6 to 12 months follow-up,all cases were satisfied with the postoperative breast shape,sensation and incision scar.Conclusion The Mckissock technique of reduction mammoplasty with vertical bipedicles preserved the ultra-thin fascia pedicle can lift the NAC effectively with tinny incision scar,and it is a safe and effective method for the patients with moderate-severe macromastia.