Objective To explore the clinical value of transumbilical single-port laparoscopic myomectomy.Methods Retrospective analysis of 93 cases with hysteromyoma performed laparoscopic myomectomy in our hospital from July 2018 to December 2022 were selected,including 44 cases of transumbilical single-port laparoscopic myomectomy(as the single-port group)and 49 cases of traditional three-hole laparoscopic myomectomy(as the control group).The incidence of adding auxiliary hole,operation time,blood loss,24-hour VAS score of pain after the operation,bed-off time,postoperative hospitalization time,postoperative complications and wound healing score were compared between the two groups.Results All 93 cases completed the laparoscopy successfully.There was no significant difference in the incidence of adding auxiliary hole during operation,operation time,blood loss volume,24-hour VAS score of pain,bed-off time of the first time after surgery,hospitalization time and complications after the operation between the two groups(P>0.05).The wound healing score of the single-port group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).In the single-port group,one auxiliary puncture hole was intraoperatively added to suture in 2 cases with difficult suturing due to uterine fibroid located in lower posterior wall.There was no conversion to open surgery,or complication such as incision bleeding,infection,hernia and adhesive intestinal obstruction in both groups.Two cases experienced delayed wound healing in the single-port group.Conclusion Both surgical interventions of transumbilical single-port and traditional multi-port laparoscopic myomectomy can achieve the same effect and high safety for hysteromyoma,while the former is safe and feasible with advantages as convenient specimen taking,ideal incision,less trauma,and which accord with the rapid rehabilitation concept,and is worthy of clinical application.