Effect of recombinant type Ⅲ collagen protein on healing of incisions after laparoscopic colorectal surgery
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维普
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目的 研究重组Ⅲ型胶原蛋白对结直肠癌腹腔镜根治术后切口愈合的作用.方法 采用回顾性队列研究.选取2022年1月至2024年6月在江阴市中医院行腹腔镜结直肠癌根治术的患者共84例,其中42例术后切口采用碘伏消毒,无菌重组Ⅲ型胶原蛋白涂抹并更换敷料(观察组),42例术后仅采用碘伏消毒并更换敷料(对照组).比较两组术后切口愈合时间,住院天数,术前、术后1 d、3 d、7 d血清白细胞介素-6(interleukin-6,IL-6)和C反应蛋白(C-reactive protein,CRP)水平以及术后切口感染,评价重组Ⅲ型胶原蛋白对腹腔镜结直肠癌根治术后切口愈合的作用.结果 ①观察组和对照组术后切口愈合时间为(6.32±0.88)d vs.(7.86±0.91)d;住院天数为(10.12±1.21)d vs.(12.57±1.38)d;对照组的术后切口愈合时间和住院时间均长于观察组,差异具有统计学意义(P＜0.001).②术前及术后1 d两组的血清IL-6和CRP水平比较无统计学差异(P＞0.05).观察组和对照组血清IL-6水平术后3 d 为(13.52±3.50)ng/L vs.(16.02±3.89)ng/L(P=0.003),术后7 d 为(9.89±1.92)ng/L vs.(11.37±2.14)ng/L(P＜0.001);血清 CRP 水平术后 3 d 为(22.89±3.33)mg/L vs.(28.09±2.65)mg/L(P＜0.001),术后7 d 为(9.03±2.43)mg/L vs.(10.25±2.18)mg/L(P＜0.001).术后 3 d 和 7 d,观察组的血清 IL-6 和CRP水平均低于对照组.③观察组术后无切口感染病例,对照组术后切口感染率为11.90％(5/42),观察组的切口感染率显著低于对照组(P＜0.05).结论 重组Ⅲ型胶原蛋白应用于腹腔镜结直肠癌根治术后切口处理,可以促进切口愈合,有助于患者早日康复,同时还能够减轻炎症反应,降低术后切口感染的发生风险.
Objective To explore the effect of recombinant type Ⅲ collagen on promoting wound healing after laparoscopic radical resection of colorectal cancer.Methods It was a retrospective cohort study.A total of 84 patients who underwent laparoscopic radical resection of colorectal cancer at Jiangyin Tradi-tional Chinese Medicine Hospital from January 2022 to June 2024 were selected.Among them,42 patients had their incisions disinfected with iodine,sterile recombinant type Ⅲ collagen and dressings changed(the observa-tion group),and 42 patients only disinfected with iodine and dressings changed after surgery(the control group).It was compared of the postoperative wound healing time,length of hospital stay,serum levels of in-terleukin-6(IL-6)and C-reactive protein(CRP)preoperatively and 1 day,3 days,7 days postoperatively.Postoperative wound infection rates were compared as well.Results ① Wound healing time of the observation group and the control group was(6.32±0.88)days vs.(7.86±0.91)days.The length of hospital stay was(10.12±1.21)days vs.(12.57±1.38)days.Wound healing time and the length of hospital stay of the control group was longer than that of the observation group,and the difference was significant(P＜0.001).②There was no significant difference in the levels of IL-6 and CRP between the two groups before and 1 day af-ter surgery(P＞0.05).The 3-day and 7-day serum postoperative IL-6 levels of the observation group and the control group was(13.52±3.50)ng/L vs.(16.02±3.89)ng/L(P=0.003),and(9.89±1.92)ng/L vs.(11.37±2.14)ng/L(P＜0.001).The 3-day and 7-day serum CRP level was(22.89±3.33)mg/L vs.(28.09±2.65)mg/L(P＜0.001),and(9.03±2.43)mg/L vs.(10.25±2.18)mg/L(P＜0.001).There were no cases of incision infection in the observation group after surgery,while the incision infection rate in the control group was 11.90％(5/42).The incision infection rate of the observation group was significantly lower than that of the control group(P＜0.05).Conclusion The application of recombinant type Ⅲ collagen protein in the treatment of incisions after laparoscopic radical resection of colorectal cancer can promote incision healing,help patients recover early,and also reduce inflammation and the risk of postoperative incision infection.
radical resection of colorectal cancerrecombinant type Ⅲ collagenwound healingpostoperative wound infection
维普
万方数据
