Objective To investigate the feasibility and safety of laparoscopic pancreatic tumor enucleation(PTE)combined with main-accessory pancreatic duct reconstruction in the treatment of pancreatic solid pseudopapillary neoplasm(PSPN).Method A retrospective analysis was conducted on a 14-year-old female patient with PSPN admitted to our hospital in February 2024 who underwent laparoscopic PTE combined with pancreatic duct stent placement with main-accessory pancreatic duct cross-bridging technique.Results The operation was successful,with an operation time of 240 minutes and an intrao-perative blood loss of about 20 mL.The patient was discharged with an abdominal drainage tube 12 days after the operation,and the drainage tube was removed 15 days after the operation.CT and MRI re-examination revealed that the pancreatic duct was unobstructed,and no exudate around the pancreas or tumor recurrence was observed in 1 and 6 months after the surgery.Conclusions Laparoscopic PTE is a feasible and safe surgical intervention for PSPN.And combined with the reconstruction of main-accessory pancreatic duct cross-bridging technique,it can achieve a good effect without postoperative pancreatic fistula.