Lipid droplet coated proteins(PLINs),also known as Periprotein/Perilipodropin,are a family of lipid droplet-related proteins participate in the regulation of lipid metabolism with the most content on the surface of lipid droplets(LDs).PLINs are participate in the biological processes of Lipid droplets formation,decomposition,and metabolism.Different PLINs have their own specific functions on the surface of lipid droplets,such as tissue distribution characteristics,subcellular location,and lipid binding characteristics.PLIN5 is highly expressed in mitochondria-rich oxidized tissues such as myocardium,mediating the interaction of LDs with mitochondria,endoplasmic reticulum and other organelles,and is closely related to the occurrence and development of multiple cardiovascular diseases(CVD).This paper reviews the structure,function and lipid regulation of PLIN5,CVD research and provided references for further researches on PLIN5.
cardiovascular diseaseslipid droplet coating protein 5lipid droplets
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