Objectives To explore the expression of anti-GPⅡb/Ⅲa and anti-GPΙb/Ⅸ antibodies in patients with primary and secondary immune thrombocytopenia(ITP),investigate the relationship between antibody positivity and bleeding scores,and analyze the differences in bleeding severity based on different antibody types.This study aims to provide clinical insights for the diagnosis,treatment,and assessment of bleeding severity in patients with primary and secondary ITP.Methods Patients diagnosed with primary ITP(42 cases)and secondary ITP(42 cases)between October 2013 and August 2020 at the First Affiliated Hospital of Xinjiang Medical University were included.Bleeding scores were assessed using the ITP bleeding score scale upon admission.The modified MAIPA method was employed to detect anti-GPⅡb/Ⅲa and anti-GPΙb/Ⅸ antibodies.Results There was no significant difference in the positivity rates of anti-GPⅡb/Ⅲa and anti-GPΙb/Ⅸ antibodies between the primary and secondary groups(P>0.05).The primary group predominantly expressed anti-GPⅡb/Ⅲa antibodies,while the secondary group showed a higher expression of anti-GPΙb/Ⅸ antibodies.The difference in the composition of positive antibodies was statistically significant(P<0.05).The overall bleeding severity was higher in the secondary group compared to the primary group(P<0.05).The relationship between antibody positivity and bleeding severity was as follows:(1)Patients positive for anti-GPⅡb/Ⅲa antibodies had a more severe bleeding degree than antibody-negative patients(P<0.05).(2)Patients positive for anti-GPΙb/Ⅸ antibodies had a more severe bleeding degree than antibody-negative patients(P<0.05),and those with dual antibody positivity had a more severe bleeding degree than antibody-negative patients(P<0.05).Conclusion The expression of anti-GPⅡb/Ⅲa and anti-GPΙb/Ⅸantibodies does not differentiate between primary and secondary ITP.However,primary ITP patients predominantly express anti-GPⅡb/Ⅲa antibodies,while secondary ITP patients express anti-GPΙb/Ⅸ antibodies.Secondary ITP patients exhibit a higher clinical bleeding severity compared to primary ITP patients.Patients positive for anti-GPⅡb/Ⅲa antibodies,anti-GPΙb/Ⅸ antibodies,and dual antibody positivity have a more severe bleeding degree than antibody-negative patients.
关键词
免疫性血小板减少症/血小板膜糖蛋白特异性抗体/出血评分
Key words
immune thrombocytopenia/platelet membrane glycoprotein specific antibody/bleeding score
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