Objective To investigate the association between serum T cell immunoglobulin and mucin domain-3(TIM-3),GATA-binding protein-3(GATA-3),and intracranial arterial plaque stability in patients with ischemic stroke.Methods A total of 124 patients diagnosed with ischemic stroke from April 2021 to April 2023 were included in this study.Based on high-resolution magnetic resonance imaging(HRMRI)results,patients were categorized into the no plaque group(19 cases),stable plaque group(28 cases),and unstable plaque group(77 cases).Serum levels of TIM-3 and GATA-3 were measured using enzyme-linked immunosorbent assay(ELISA).Receiver operating characteristic(ROC)curves were used to assess the predictive value of serum TIM-3 and GATA-3 for intracranial arterial plaque stability in ischemic stroke patients.Multiple logistic regression analysis was performed to explore factors influencing intracranial arterial plaque stability in ischemic stroke patients.Results The prevalence of hypertension,degree of intracranial arterial stenosis,levels of high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),homocysteine(Hey),and C-reactive protein(CRP)differed significantly among the no plaque group,stable plaque group,and unstable plaque group(P＜0.05).Serum levels of TIM-3 and GATA-3 also showed significant differences among the three groups(P＜0.05).Further pairwise comparisons revealed that serum TIM-3 levels were higher in the stable and unstable plaque groups compared to the no plaque group(P＜0.05),and serum TIM-3 levels were higher in the unstable plaque group compared to the stable plaque group(P＜0.05).Serum GATA-3 levels were lower in the stable and unstable plaque groups compared to the no plaque group(P＜0.05),and the unstable plaque group had lower serum GATA-3 levels than the stable plaque group(P＜0.05).The ROC curve analysis showed that the combination of TIM-3 and GATA-3 had the highest area under the curve(AUC)of 0.903(95％CI:0.846,0.957),specificity of 85.7％(95％CI:0.832,0.943),and sensitivity of 84.0％(95％CI:0.795,0.892)in predicting intracranial arterial plaque stability in ischemic stroke patients.Multiple logistic regression analysis identified high-degree intracranial arterial stenosis[(^OR)=2.016(95％CI:1.419,2.863)],elevated Hey levels[(^OR)=2.323(95％CI:1.567,3.445)],TIM-3 ≥ 393.78 ng/L[(^OR)=3.022(95％CI:1.903,4.800)],and GATA-3≤38.49 ng/L[OR=2.497(95％CI:1.645,3.790)]as independent risk factors for unstable intracranial arterial plaques in ischemic stroke patients(P＜0.05).Conclusion Elevated TIM-3 and reduced GATA-3 levels are associated with decreased intracranial arterial plaque stability in ischemic stroke patients.Both markers can serve as serum biomarkers for predicting intracranial arterial plaque stability in these patients.
关键词
缺血性脑卒中/T细胞免疫球蛋白黏蛋白分子-3/GATA结合蛋白-3/颅内动脉斑块/稳定性
Key words
ischemic stroke/T-cell immunoglobulin and mucin domain-containing protein 3/GATA-binding protein-3/intracranial plaque/stability
维普
万方数据