The interaction between maternal circadian rhythm signaling and circadian clock genes may affect the development of the placenta and the fetus,leading to outcomes such as gestational diabetes mellitus,preeclampsia,miscarriage,premature birth,and abnormal development of offspring.This review summarizes the associations of circadian clock genes with maternal conditions as well as placental and fetal development,and how circadian clock genes induce the occurrence of adverse pregnancy outcomes via the maternal-fetal interface,so as to predict the impact of related risks on the offspring,to improve the risk management of pregnancy complications and the accuracy of disease control and prevention programs,and to provide important guidelines for human reproductive health.
关键词
妊娠期糖尿病/子痫前期/生物钟基因/流产/早产/子代发育
Key words
circadian clock gene/gestational diabetes mellitus/preeclampsia/miscarriage/premature birth/offspring development
维普
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