Recent studies have shown that gut microbiota has important physiological functions such as regulating body barriers and influencing metabolic activities,and is also an important pathogenic factor and regulatory medium.Endothelial cells play an important role in the pathogenesis of vascular diseases.Endothelial damage is a risk factor for cardiovascular diseases.Disturbance of gut microbiota is related to various diseases,and the imbalance of gut microbiota and its metabolites mediates the inflammation and oxidative stress state of vascular endothelium,inducing vascular endothelial damage.This article reviews the mechanism of the involvement of gut microbiota in vascular endothelial injury and related intervention strategies,providing new ideas and directions for the intervention of vascular endothelial injury from the perspective of gut microbiota and its downstream.
关键词
肠道菌群失调/血管内皮损伤/作用机制
Key words
gut microbiota imbalance/vascular endothelial injury/mechanisms
维普
万方数据