Inflammatory bowel disease(IBD)comprises a group of chronic non-specific inflammatory conditions affecting the gastrointestinal tract.The pathogenesis of IBD is complex,with damage to the intestinal mucosal barrier being a central component.Various pathological stimuli trigger abnormal cell death in intestinal epithelial cells,providing the pathological basis for bacterial invasion of the intestinal wall and subsequent inflammatory reactions.In recent years,in addition to apoptosis,autophagy,and necroptosis,various novel forms of regulated cell death(RCD),such as pyroptosis,ferroptosis,and copper-dependent cell death,have been implicated in the progression of IBD.Multiple forms of RCD can modulate the intestinal mucosal barrier,immune responses,and gut microbiota,impacting the progression of IBD.Targeting RCD for therapy effectively alleviates colonic inflammation.This paper comprehensively and systematically summarizes the mechanisms by which various forms of RCD contribute to the pathogenesis of IBD,aiming to provide a comprehensive understanding of the regulatory mechanisms of RCD in IBD and offer new targets and strategies for clinical treatment.
维普
万方数据