Objective To investigate the correlation between apoptosis-associated speck-like protein containing a CARD autoantibodies(NAbs-ASC)and total cholesterol(TC)levels with Alzheimer's disease(AD).Methods A total of 38 AD patients from the Neurology Department of Daping Hospital,Army Medical University,between October and December 2022,were selected,along with 38 healthy individuals from the Health Management Department as the control group.Plasma levels of NAbs-ASC and TC were compared between the two groups,and the correlation between NAbs-ASC,TC,and AD was analyzed.Results The plasma levels of NAbs-ASC in the AD group were lower than those in the control group(P＜0.05),while the TC levels were higher(P＜0.05).Spearman correlation analysis showed a negative correlation between NAbs-ASC levels and TC levels(rs =-0.290,P＜0.05),a negative correlation between cognitive function levels and TC levels(rs =-0.380,P＜0.05),and a positive correlation between plasma NAbs-ASC levels and cognitive function levels(rs = 0.550,P＜0.05).Multifactorial logistic regression analysis showed that elevated TC was a risk factor for AD[(OR) = 3.004(95%CI:1.075,8.396)],while elevated NAbs-ASC was a protective factor for AD[(OR) = 0.998(95%CI:0.997,0.999)].Conclusions The decrease in NAbs-ASC and the increase in TC are correlated with AD and are associated with the decline in cognitive function.
关键词
阿尔茨海默病/凋亡相关斑点样蛋白自身抗体/总胆固醇/认知功能
Key words
Alzheimer disease/apoptosis-associated speck-like protein containing a CARD autoantibodies/total cholesterol/cognitive function
维普
万方数据