Ovarian cancer is a gynecological malignant tumor with the highest mortality rate.Patients with ovarian cancer are prone to relapse and death due to chemotherapy resistance,with a five-year survival rate of only about 40%.Circular RNAs(circRNAs)are single-stranded,covalently closed non-coding RNAs.They are stable and abundant in the cell nucleus,cell cytoplasm,and body fluids of organisms,and have become a hot topic in the field of ovarian cancer regulation in recent years.This review systematically summarizes 62 circRNAs associated with the regulation of ovarian cancer in terms of apoptosis,epithelial-mesenchymal transition,cell cycle,autophagy,and biomarkers,including 15 circRNAs that are significantly associated with cisplatin and taxane resistance in ovarian cancer.Additionally,the molecular mechanisms underlying the roles of circRNAs in regulating development and chemoresistance of ovarian cancer are reviewed from the perspectives of competing endogenous RNA,functional protein-protein interaction,peptide and protein synthesis,and signaling pathways,so as to provide insights for future studies on roles of circRNAs in regulating development and chemoresistance of ovarian cancer.
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