The hypothalamic KiSS1 system is an essential component of the hypothalamic-pituitary-gonadal axis,and regulates the reproductive function by promoting the secretion of gonadotropin hormone-releasing hormone(GnRH).Recent studies have identified the effects of prenatal stress on the reproductive function of male offspring.However,the mechanisms underlying the prenatal stress-induced decline in reproductive function in male offspring remain elusive.Treatment targeting the hypothalamic KiSS1 system may improve the reproductive function of prenatally stressed male offspring.This review will discuss the potential roles of the KiSS1 system in prenatal stress-induced reproductive dysfunction in male offspring.
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