Pruritus is an unpleasant sensation that causes itching.Various skin diseases,systemic diseases,neurological disorders,and psychological conditions can all trigger pruritus,and its pathogenesis is complex.Interleukin-13(IL-13)is a type 2 cytokine that plays a significant role in pruritus.IL-13 is mainly secreted by T helper 2(Th2)cells and,through binding with the IL-13 receptor alpha 1(IL-13Rα1)and interleukin-4 receptor alpha(IL-4Rα)heterodimer,it can directly cause itching or indirectly promote the release of other pruritus factors.This article reviews the cellular sources,signaling pathways,mechanisms of action in pruritus,and the latest developments in targeted therapeutic drugs for IL-13 and its receptors.
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