Epilepsy is one of the most common nervous system diseases.Cognitive impairment is a common complication of epilepsy and seriously affects the quality of life of patients.However,the pathogenesis of cognitive impairment in epilepsy is complex and has not been clearly studied yet.Synaptic plasticity is an important mechanism underlying the occurrence of epilepsy and cognitive impairment.In recent years,more and more studies have confirmed that cell adhesion molecule nectin-1 plays an essential role in synaptic plasticity.Nectin-1 is abnormally expressed in the hippocampus of rat models of epilepsy,and causes epilepsy and cognitive impairment by affecting the synaptic plasticity.This review summarizes the possible roles of cell adhesion molecule nectin-1 in cognitive impairment in epilepsy with a view to exploring potential intervention measures.
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