Objective To explore the value of nuchal translucency(NT)in the diagnosis of fetal malformation and the prediction of fetal health during early pregnancy.Methods The 210 pregnant women with a thickened fetal NT in Sanya Maternal and Child Health Hospital from January 2019 to October 2022 were selected.The fetal NT thickness was compared between fetuses with and without structural abnormalities and chromosomal abnormalities,and between those with normal delivery and adverse pregnancy outcomes.Results Among 210 pregnant women,87 cases(41.43％)were finally diagnosed with structural abnormalities,of which 50 cases had multiple structural abnormalities.Sixty-eight cases(32.38％)were diagnosed as chromosomal abnormalities.The fetal NT thickness of pregnant women with fetal structural abnormalities was higher than that of pregnant women without structural abnormalities(P＜0.05).The fetal NT thickness of pregnant women with fetal chromosomal abnormalities was higher than that of pregnant women without chromosomal abnormalities(P＜0.05).The receiver operating characteristic(ROC)curve analysis revealed that the area under the ROC curve of fetal NT thickness for diagnosing fetal structural abnormalities was 0.879(95％CI:0.832,0.927)with a cutoff value of 4.21 mm,and the sensitivity and specificity were 88.50％(95％CI:0.810,0.930)and 75.60％(95％CI:0.700,0.805),respectively.The area under the ROC curve of fetal NT thickness for diagnosing fetal chromosomal abnormalities was 0.840(95％CI:0.785,0.896)with a cutoff value of 4.30 mm,and the sensitivity and specificity were 88.20％(95％CI:0.803,0.940)and 66.90％(95％CI:0.603,0.760),respectively.The fetal NT thickness in those with normal delivery was lower than that in those with adverse pregnancy outcomes(P＜0.05).The area under the ROC curve of fetal NT thickness for predicting adverse pregnancy outcomes was 0.833(95％CI:0.780-0.887)with a cutoff value of 4.52 mm,and the sensitivity and specificity were 66.30％(95％CI:0.610,0.723)and 84.30％(95％CI:0.760,0.910),respectively.Conclusion NT is of great value in predicting fetal structural and chromosomal abnormalities and adverse pregnancy outcomes,which warrants further study.
维普
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