Effects of less invasive surfactant administration combined with budesonide on inflammatory markers and adverse reactions in neonates with bronchopulmonary dysplasia
Objective To explore the effects of Less Invasive Surfactant Administration(LISA)combined with budesonide on inflammatory markers and adverse reactions in neonates with Bronchopulmonary Dysplasia(BPD).Methods A total of 108 neonates with BPD treated at the Changzhou Maternity and Child Health Care Hospital from January 2021 to January 2023 were enrolled and randomly divided into a control group and an observation group,with 54 cases in each.The control group received a mixture of surfactant and budesonide via traditional endotracheal intubation,while the observation group received the same mixture via LISA.Blood gas indices(pH,partial pressure of carbon dioxide[PaCO2],and partial pressure of oxygen[Pa02]),levels of inflammatory markers(tumor necrosis factor-α[TNF-α],interleukin-6[IL-6],and interleukin-8[IL-8]),and stress indicators(cortisol[Cor]and adrenocorticotropic hormone[ACTH])were measured before treatment and 24 hours after medication administration.The BPD grade,duration of non-invasive ventilation,total duration of oxygen dependence,length of hospital stay,catheterization failure rate,and incidence of adverse reactions during treatment were also compared between the two groups.Results The differences in pH,PaO2,PaCO2,inflammatory factor levels and stress index levels in the observation group were higher than those in the control group(P＜0.05).The proportion of moderate to severe BPD,the duration of non-invasive ventilation,the total time of oxygen dependence,the length of hospital stay,the failure rate of catheterization and the incidence of adverse reactions were lower than those in the control group(P＜0.05).Conclusion The use of LISA technique combined with budesonide in the treatment of neonatal BPD can enhance therapeutic outcomes and reduce stress and adverse reactions in affected infants.
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