Effects of nasal intermittent positive pressure ventilation combined with bovine pulmonary surfactant on respiratory mechanics in neonates with respiratory distress syndrome
Effects of nasal intermittent positive pressure ventilation combined with bovine pulmonary surfactant on respiratory mechanics in neonates with respiratory distress syndrome
Objective To analyze the effects of nasal intermittent positive pressure ventilation(NIPPV)combined with different doses of bovine pulmonary surfactant on neonates with respiratory distress syndrome(RDS).Methods A total of 98 neonates with RDS treated at Northwest Women and Children's Hospital from October 2021 to October 2023 were randomly divided into two groups of 49 cases each.All neonates received NIPPV.In addition,the control group received 60 mg/kg of bovine pulmonary surfactant,while the observation group received 100 mg/kg.Treatment duration,blood gas indices,respiratory mechanics parameters(tidal volume,peak tidal expiratory flow[PTEF],minute ventilation[MV],time to peak ratio),lung injury markers,cerebral oxygen metabolism indices(regional cerebral oxygen saturation[rSO2],jugular venous oxygen saturation[SjVO2]),and complication rates were recorded and compared between the two groups.Results The treatment duration in the observation group was significantly shorter than in the control group(P＜0.05).The differences in oxygenation index(OI),partial pressure of oxygen(PaO2),oxygen saturation(SpO2),partial pressure of carbon dioxide(PaCO2),lung injury markers,respiratory mechanics,and cerebral oxygen metabolism indices before and after treatment were significantly greater in the observation group compared to the control group(P＜0.05).The incidence of complications was also lower in the observation group(P＜0.05).Conclusion The combination of high-dose bovine pulmonary surfactant with NIPPV significantly improves respiratory mechanics in neonates with RDS and reduces the risk of complications.
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