Ischemic stroke refers to the neurological damage caused by various cerebral vascular diseases.Severe infection induced by immunosuppression after stroke is an important factor affecting the survival and prognosis of patients.Although antibiotic therapy is effective to a certain extent,immunomodulatory therapy has received a lot of attention as drug resistance has increased.invariant Natural Killer T-cells(iNKT)play an important role in post-stroke immunosuppression,acting as upstream modulators of CD4+T and CD8+T Cells in the immune system to induce the changes from Th1 to Th2.Which leads to post-stroke immunosuppression.Regulating iNKT cells directly with alpha-galactoceramide(alpha-Galcer)or by blocking norepinephrinic neurotransmitters is known to help reduce infection rates after stroke.But the mechanism of how iNKT cells are activated at a distance and how they drive changes in the immune system after stroke has been unclear.This article reviews the biological characteristics,functions and effects of iNKT cells on post-stroke immunosuppression.
维普
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