The impact of probiotic supplements combined with insulin aspart on gut microbiota and maternal-infant outcomes in patients with gestational diabetes mellitus
Objective To investigate the impact of probiotic supplements combined with insulin aspart on the gut microbiota and maternal-infant outcomes in patients with gestational diabetes mellitus.Methods Between April 2020 and April 2023,a total of 104 patients with gestational diabetes mellitus treated in Chengdu Seventh People's Hospital were selected for this study.By using the random number table method,the patients were divided into a control group(treated with insulin aspart)and a combination group(treated with probiotic supplements in addition to insulin aspart),with 52 cases in each group.The indicators of glucose metabolism,resistance to umbilical blood flow,and gut microbiota structures before and after the treatment as well as maternal-infant outcomes and the incidence of adverse reactions were compared between the two groups.Results The differences in levels of fasting blood glucose,2-h postprandial blood glucose,glycated hemoglobin,and insulin resistance index(HOMA-IR)before and after the treatment in the combination group were greater than those in the control group(P＜0.05).The differences in the pulsatility index,resistive index,and the systolic/diastolic ratio before and after the treatment in the combination group were greater than those in the control group(P＜0.05).Besides,the differences in the frequencies of Lactobacillus,Bifidobacterium,and Escherichia coli before and after the treatment in the combination group were also greater than those in the control group(P＜0.05).The overall incidence of adverse pregnancy outcomes and neonatal outcomes in the combination group was lower than that in the control group(P＜0.05).The overall incidence of adverse reactions did not differ significantly between the two groups(P＞0.05).Conclusions The treatment regimen combining probiotic supplements with insulin aspart can effectively improve the gut microbiota homeostasis and optimize glycemic control in patients with gestational diabetes mellitus,and thereby contribute to better maternal-infant outcomes.The treatment is safe and worthy of being widely applied in clinical practice.
国家科技期刊平台
NSTL
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