Sepsis-induced cardiomyopathy(SICM)represents a frequent sepsis complication,with its underlying mechanisms remain incompletely understood.Extensive research has established the gut microbiota's association with various cardiovascular diseases;however,insights into its impact on SICM remain limited.Recent investigations beyond established mechanisms have identified potential influences on SICM through the gut-heart or gut-kidney-heart axis,including dysbiosis of the gut microbiome,impairment of the mucosal barrier,microbial translocation,metabolic dysregulation,mitochondrial dysfunction,and inflammatory responses.This review aims to delve into the potential interplay between gut microbiota alterations during sepsis and SICM.Enhancing our understanding of these connections could pave the way for improved therapeutic approaches to sepsis and better prognoses for affected individuals.
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