Cerebral small vessel disease(CSVD)is a group of highly heterogeneous cerebrovascular diseases involving arterioles,venules,and capillaries.Unlike macrovascular disease,direct monitoring of CSVD progression in vivo remains a challenge.In addition,due to the complexity of CSVD,its pathogenesis has not been fully elucidated,and there is still a lack of effective treatment.Therefore,in this paper,the characteristics,advantages,and disadvantages of many CSVD animal models in recent years were sorted out and analyzed,in order to jointly explore the future research direction of CSVD treatment.
cerebral small vessel diseaseanimal modelresearch progress