Non-alcoholic fatty liver disease(NAFLD)is a clinical and pathological syndrome characterized by excessive lipid accumulation in hepatocytes,excluding other factors such as long-term excessive alcohol consumption.As the global incidence and prevalence of NAFLD continue to rise annually,increasing research has focused on the disease's pathogenesis.However,the experimental models used for NAFLD research,particularly animal models,vary significantly.This review summarizes the recent progress in NAFLD research models,with a particular emphasis on animal and cell models,providing references for researchers studying NAFLD.