Proportion of red blood cells and fibrin components in thrombi of acute ischemic stroke patients and their impact on prognosis
Objective To investigate the proportion of red blood cells(RBCs)and fibrin components in thrombi of acute ischemic stroke(AIS)patients and their impact on prognosis.Methods A total of 102 AIS patients treated with mechanical thrombectomy at Dongguan People's Hospital from January 2021 to January 2024 were enrolled.Based on the modified Thrombolysis in Cerebral Infarction(mTICI)grading for vascular recanalization,patients were divided into a good prognosis group(66 cases)and a poor prognosis group(36 cases).Perioperative modified Rankin Scale(mRS)scores,C-reactive protein(CRP)levels,neutrophil-to-lymphocyte ratio(NLR),homocysteine levels,proportions of high fibrin/platelet thrombi,and high RBC thrombi were compared between the two groups.Multivariate stepwise logistic regression was used to analyze factors associated with poor prognosis in AIS patients.Results At 24 hours postoperatively and before discharge,the mRS scores were significantly higher in the poor prognosis group compared to the good prognosis group(P＜0.05).CRP levels,NLR,and homocysteine levels were significantly elevated in the poor prognosis group compared to the good prognosis group(P＜0.05).The proportion of high fibrin/platelet thrombi was higher,while the proportion of high RBC thrombi was lower in the poor prognosis group(P＜0.05).Multivariate logistic regression analysis indicated that elevated CRP levels[OR=3.702(95％CI:1.607,8.529)],increased NLR[OR=3.615(95％CI:1.569,8.327)],higher homocysteine levels[OR=4.076(95％CI:1.769,9.389)],and a higher proportion of fibrin/platelet thrombi[OR=3.741(95％CI:1.623,8.615)]were independent risk factors for poor prognosis in AIS patients(P＜0.05).Conclusion A higher proportion of fibrin/platelet components in thrombi is closely associated with poor prognosis in AIS patients.
万方数据
维普
