Effect of metoprolol tablets combined with trimetazidine tablets on patients with stable angina pectoris
Objective To analyze the effect of metoprolol tablets combined with trimetazidine tablets on patients with stable angina pectoris(SAP).Methods 86 patients with SAP were randomly divided into the observation group and the control group,with 43 cases in each group.The control group was given conventional treatment,while the observation group was given metoprolol tablet + trimetazidine tablets.Comparison was made on Seattle Angina Questionnaire(SAQ)scores(disease awareness,angina stable state,angina attacks,activity limits scores),angina attacks before and after treatment,quality of life scores(general health,energy,social functioning,mental health,physical pain,somatic role functioning,emotional role functioning,physical health scores),and cardiotrophin-1(CT-1)and reactive oxygen species(ROS)between the two groups.Results After treatment,the frequency of angina attacks in the observation group was(1.55±0.44)times per week,which was less than that of(3.08±0.55)times per week in the control group,and the duration of angina attacks was(1.68±1.18)min/time,which was shorter than that of(3.48±1.48)min/time in the control group(P<0.05).In the observation group,the disease awareness score was(16.55±1.97)points,the angina stable state score was(15.35±1.76)points,the angina attack score was(19.06±2.12)points and the activity limit score was(58.17±6.50)points,which were higher than those of(12.41±1.57),(10.68±1.23),(14.17±1.83)and(49.75±5.66)points in the control group(P<0.05).After treatment,in the observation group,the overall health score was(63.26±4.49)points,the energy score was(74.26±4.55)points,the social function score was(83.66±3.92)points,the mental health score was(81.49±4.26)points,the somatic pain score was(74.49±6.39)points,and the somatic role functioning score was(73.53±4.19)points,the emotional role functioning score was(84.53±3.68)points and the somatic health score was(71.38±4.29)points,which were higher than those of(54.55±3.26),(61.23±4.02),(76.33±2.76),(61.25±3.76),(66.59±4.71),(61.23±4.43),(73.06±2.51)and(52.30±2.77)points in the control group(P<0.05).After treatment,CT-1 of(42.51±4.95)pg/L and ROS of(550.01±56.96)U/ml in the observation groups were lower than those of(55.01±6.06)pg/L and(645.75±66.01)U/ml in the control group(P<0.05).Conclusion The combination of metoprolol tablets and trimetazidine tablets has significant therapeutic effects in the treatment of SAP,which can effectively improve the level of CT-1 and ROS of patients,reduce the frequency of angina attacks,shorten the duration of angina attacks,and improve the disease awareness,stable state of angina and quality of life of patients,which is safe and worthy of promotion and application.
Stable angina pectorisMetoprolol tabletsRoutine treatmentNumber of seizuresTrimetazidine tablets
NETL
NSTL
万方数据
维普
