Observation on anesthesia effect of low-dose esketamine compounded with propofol in painless colonoscopy
Objective To observe the anesthesia effect of low-dose esketamine compounded with propofol in painless colonoscopy.Methods 68 outpatients who underwent painless colonoscopy were divided into an observation group and a control group according to random numerical table,with 34 cases in each group.The observation group was given low dose esketamine + propofol for anesthesia,and the control group was given propofol only for anesthesia.Comparison was made on vital signs[mean arterial pressure(MAP),heart rate(HR),and oxygen saturation(SpO2)]at different time points[before anesthesia(T1),at the time of enteroscopy(T2),during enteroscopy to the splenic flexure(T3),during enteroscopy to the hepatic flexure(T4),and during enteroscopy to the ileocecal valve(T5)],anesthesian-related indicators(onset of anesthesia,time to awakening,total propofol dosage,apparent body movement),sedative and analgesic effect,and occurrence of adverse events.Results At T1,there was no statistically significant difference in MAP,HR and SpO2 between the two groups(P>0.05).At T2,T3,T4 and T5,MAP,HR and SpO2 in both groups were lower than those at T1,but MAP,HR and SpO2 in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The onset of anesthesia of(19.38±3.23)s and time to awakening of(7.92±1.41)min in the observation group were shorter than those of(30.74±3.60)s and(12.41±1.38)min in the control group;the total propofol dosage of(106.00±16.05)mg in the observation group was lower than that of(147.44±18.34)mg in the control group;the proportion of apparent body movement of 35.3%in the observation group was lower than that of 67.6%in the control group;the differences were statistically significant(P<0.05).The excellent rate of sedation and analgesia in the observation group was 64.7%,which was higher than that of 32.4%in the control group,the difference was statistically significant(P<0.05).The incidence rates of injection pain,circulatory depression,respiratory depression and bradycardia in the observation group were 17.6%,11.8%,14.7%and 8.8%,which were significantly lower than those of 55.9%,38.2%,44.1%and 35.3%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of nausea and vomiting between the two groups(P>0.05).Conclusion The combination of low-dose esketamine and propofol provides ideal effect of sedation and analgesia in painless colonoscopy.Compared with propofol alone,patients'vital signs are more stable and safer.
NETL
NSTL
万方数据
维普
