Correlation of ECHO characteristics and serological indexes changes with NYHA classification in HFpEF patients
Objective To discuss the correlation of echocardiogram(ECHO)characteristics and serological indexes changes with New York Heart Association(NYHA)classification in heart failure with preserved ejection fraction(HFpEF)patients.Methods A total of 120 HFpEF patients were selected as HFpEF group.According to NYHA classification,the patients in HFpEF group were divided into class Ⅱ group(42 cases),classⅢ group(43 cases),and class Ⅳ group(35 cases).In addition,121 healthy subjects in the same period were selected as the non-heart failure group.ECHO parameters[left ventricular posterior wall thickness(LVPW),in-terventricular septum thickness(IVS),left atrial diameter(LAD),left atrial volume index(LAVI),tricuspid regurgitant velocity(TRV),left ventricular end-diastolic diameter(LVDd),left ventricular end-systolic diameter(LVsD)and left ventricular ejection fraction(LVEF)],ratio of mitral early flow velocity to mitral late flow velocity(E/A)],blood uric acid(BUA)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)levels were detected and compared between HFpEF group and non-heart failure group.Serum BUA and NT-proBNP levels of patients with different NYHA classification in HFpEF group were compared.The correlation of serum BUA,NT-proBNP levels with NYHA classification in HFpEF patients was analyzed.Results LAD,LVDd,LVDs,E/A,LAVI and TRV in HFpEF group were(45.37±5.95)mm,(49.75±5.72)mm,(33.72±3.84)mm,(0.74±0.11),(45.52±5.53)ml/m2 and(2.94±0.31)m/s,which were higher than those of(32.82±4.85)mm,(41.51±5.28)mm,(26.16±3.43)mm,(0.52±0.09),(20.64±3.41)ml/m2 and(2.18±0.35)m/s in non-heart failure group;LVEF of(61.24±7.86)%in HFpEF group was lower than that of(68.23±7.98)%in non-heart failure group;the difference was statistically significant(P<0.05).There was no statistically significant difference in IVS and LVPW between the two groups(P>0.05).The serum BUA and NT-proBNP in HFpEF group were(486.88±68.91)μmol/L and(874.07±112.71)pg/ml,respectively,which were higher than those of(287.87±35.82)μmol/L and(121.57±16.26)pg/ml in non-heart failure group,and the difference was statistically significant(P<0.05).In classⅡ group,serum BUA and NT-proBNP were(345.67±47.82)μmol/L and(613.63±72.45)pg/ml,respectively.In class Ⅲ group,serum BUA and NT-proBNP were(512.14±63.59)μmol/L and(863.46±94.84)pg/ml,respectively.In class Ⅳ group,serum BUA and NT-proBNP were(625.31±72.42)μmol/L and(1199.62±137.51)pg/ml,respectively.The serum BUA and NT-proBNP levels of patients with different NYHA classification in HFpEF group were significantly different(P<0.05).The levels of serum BUA and NT-proBNP in class Ⅲand Ⅳ groups were higher than those in class Ⅱ group,and that in class Ⅳ group was higher than that in classⅢ group.The difference was statistically significant(P<0.05).Pearson correlation coefficient analysis showed that serum BUA and NT-proBNP levels were positively correlated with NYHA classification in HFpEF patients(r=0.476,0.474;P<0.05).Conclusion Abnormal ECHO index can assist the judgment of HFpEF.The higher the level of serum BUA and NT-proBNP in the patient,the higher the NYHA classification of the patient,and the more serious the cardiac function impairment.Clinically,the detection of serum BUA and NT-proBNP levels can assist clinicians to judge the condition and cardiac function impairment of patients with HFpEF,so as to provide targeted treatment for patients as soon as possible and improve the prognosis of patients.
Heart failure with preserved ejection fractionEchocardiogramSerological indexesCardiac function classification
NETL
NSTL
万方数据
维普
