Study on clinical effect of continuous blood purification on patients with multiple-organ dysfunction syndrome
Objective To discuss the clinical effect of continuous blood purification(CBP)on patients with multiple-organ dysfunction syndrome and its influence on serum inflammatory factors.Methods A total of 60 patients with multiple-organ dysfunction syndrome were divided into a control group and a study group according to random numerical table,with 30 cases in each group.The control group was treated with conventional regimen,and the study group was treated with continuous blood purification based on the control group.Both groups were compared in terms of therapeutic effect,multiple-organ dysfunction syndrome scores,hemorheology indexes,inflammatory factors[C-reactive protein(CRP),interleukin-10(IL-10),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels before and after treatment.Results The total effective rate in the study group was 97%,which was higher than that of 80%in the control group,and the difference was statistically significant(P<0.05).After treatment,the score of multiple-organ dysfunction syndrome in the study group was(8.05±2.62)points,which were lower than that of(16.51±3.90)points in the control group,and the differences were statistically significant(P<0.05).After treatment,the platelet adhesion rate,plasma viscosity and whole-blood high-shear viscosity were(30.08±10.97)%,(1.09±0.01)and(3.98±0.03)mPa·s in the study group,which were lower than those of(57.62±15.28)%,(1.52±0.09)and(5.88±0.14)mPa·s in the control group,and the difference were statistically significant(P<0.05).After treatment,CRP,IL-10,IL-6 and TNF-α were(80.02±10.97)mg/L,(51.97±6.93)ng/ml,(101.03±10.28)ng/ml and(64.55±8.57)pg/ml in the study group,which were lower than those of(104.62±15.28)mg/L,(90.23±10.96)ng/ml,(124.32±8.09)ng/ml and(90.02±12.94)pg/ml in the control group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of continuous blood purification in patients with multiple-organ dysfunction syndrome is remarkable,and can stable the vital signs of patients,improve the inflammatory level,and improve the quality of life of patients,which is worthy of clinical popularization.
NETL
NSTL
万方数据
维普
