The application value of serum bilirubin and uric acid detection in the assessment of coronary heart disease risk factors
Objective To analyze the evaluation value of serum bilirubin and uric acid(UA)detection in the assessment of coronary heart disease risk factors.Methods 100 patients undergoing coronary angiography were divided into a study group(coronary heart disease,60 cases)and a control group(non-coronary heart disease,40 cases)according to the results of coronary angiography.Patients in the study group were divided into single-vessel group(single vessel disease,11 cases)and multi-vessel group(double or more vessel disease,49 cases)according to the number of coronary vascular lesions.According to different degree of coronary artery stenosis,the patients were divided into mild group(stenosis<75%,22 cases)and severe group(stenosis≥75%,38 cases).The levels of serum bilirubin[total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL)]and blood UA were compared between the study group and the control group,and the levels of serum bilirubin and blood UA in patients with different number of coronary vascular lesions and stenosis degree in the study group.Results The serum TBIL in the study group was(9.23±1.16)μmol/L,DBIL was(0.99±0.17)μmol/L and IBIL was(8.52±2.17)μmol/L,which were lower than those of(14.37±3.12),(3.53±1.06)and(10.41±2.75)μmol/L in the control group;the serum UA of(392.78±70.22)μmol/L in the study group was higher than that of(280.47±45.15)μmol/L in the control group;the difference was statistically significant(P<0.05).The serum TBIL in multi-vessel group was(8.02±2.35)μmol/L,DBIL was(0.77±0.27)μmol/L and IBIL was(7.09±1.23)μmol/L,which were lower than those of(10.19±2.17),(1.26±0.29)and(9.47±1.19)μmol/L in single-vessel group;the serum UA of(430.99±54.18)μmol/L in multi-vessel group was higher than that of(322.89±30.21)μmol/L in single-vessel group;the difference was statistically significant(P<0.05).The serum TBIL in severe group was(7.44±2.62)μmol/L,DBIL was(0.69±0.22)μmol/L and IBIL was(6.79±1.31)μmol/L,which were lower than those of(10.53±1.86),(1.36±0.23)and(10.95±1.27)μmol/L in mild group;the serum UA of(491.17±73.55)μmol/L in severe group was higher than that of(316.11±42.88)μmol/L in mild group;the difference was statistically significant(P<0.05).Conclusion Serum bilirubin and blood UA are simple,convenient and popular biochemical indicators for predicting and diagnosing coronary heart disease.Detection of serum bilirubin and blood UA in patients with coronary heart disease can clarify the severity of the disease,better control the occurrence and development of coronary heart disease,and reduce the medical consumption and expenditure of patients and the country.
Serum bilirubinUric acidCoronary heart diseaseEvaluation value
NETL
NSTL
万方数据
维普
