Effectiveness appraisal of trimebutine maleate plus esomeprazole in treating gastroesophageal reflux disease
Objective To study the effectiveness of trimebutine maleate plus esomeprazole in treating gastroesophageal reflux disease(GERD).Methods 70 patients with gastroesophageal reflux disease were divided into a control group and a study group according to random numerical table,with 35 cases in each group.The control group was treated with esomeprazole,and the study group was treated with esomeprazole and trimebutine maleate.Comparison was made on clinical efficacy,symptom scores,inflammatory factors and quality of life scores before and after treatment between the two groups.Results The total effective rate of treatment of 88.57%in the study group was higher than that of 68.57%in the control group,and the difference was statistically significant(P<0.05).After 2 months of treatment,the scores of acid regurgitation,heartburn,substernal chest pain and food regurgitation were(0.89±0.22),(0.73±0.21),(0.65±0.11)and(0.96±0.21)points in the study group,which were lower than those of(1.65±0.45),(1.78±0.55),(1.56±0.31)and(3.05±0.42)points in the control group,and the differences were statistically significant(P<0.05).After 2 months of treatment,the C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were(9.95±1.21)mg/L,(8.96±2.23)pg/ml and(7.41±0.85)pg/ml in the study group,which were lower than those of(12.45±2.31)mg/L,(13.42±2.75)pg/ml and(10.65±1.65)pg/ml in the control group,and the difference was statistically significant(P<0.05).After 2 months of treatment,the scores of psychological function,social function,physical function and material life were(82.21±6.44),(80.23±6.54),(84.23±6.34)and(85.34±5.45)points in the study group,which were higher than those of(70.34±7.34),(68.45±7.65),(70.54±7.54)and(72.56±6.34)points in the control group,and the difference was statistically significant(P<0.05).Conclusion The trimebutine maleate plus esomeprazole has ideal effect on gastroesophageal reflux disease,which can improve the related symptoms,reduce levels of inflammatory factors,and increase the quality of life of patients,and is worthy of clinical application.
NETL
NSTL
万方数据
维普
