Study on effect and mechanism of transcutaneous electrical acupoint stimulation combined Junzi Xiaopi Decoction in treating diabetic gastroparesis
Objective To observe the efficacy of transcutaneous electrical acupoint stimulation(TEAS)combined with Junzi Xiaopi Decoction in the treatment of diabetic gastroparesis(DGP),and explore the mechanism.Methods 64 patients diagnosed DGP as study subjects were divided into group A,group B,group C and group D under the clinical trial of the central randomized system,with 16 cases in each group.Group A:4 weeks of TEAS treatment,stop 2 weeks,4 weeks of conventional treatment;group B:4 weeks of Junzi Xiaopi Decoction treatment,stop 2 weeks,4 weeks of conventional treatment;group C:4 weeks of TEAS + Junzi Xiaopi Decoction treatment,stop 2 weeks,4 weeks of conventional treatment;group D:4 weeks of conventional treatment,stop 2 weeks,4 weeks of TEAS + Junzi Xiaopi Decoction treatment.Comparison was made on quality of life[physical function(PF),role emotional(RE),social function(SF),mental health(MH),role physical(RP),vitality(V),body pain(BP)and general health(GH)in 36-item short-form health survey(SF-36)],gastric emptying function[half-emptying time(T1/2)and gastric residue rate within 120 min]before and after treatment,and efficacy among the four groups,and the safety of the four groups was analyzed.Results After treatment,the scores of PF,MH,V,BP and GH in the four groups were significantly higher than before treatment,the difference was statistically significant(P＜0.05).After treatment,the scores of RE,SF and RP among the four groups were not statistically significant from those before treatment(P＞0.05).After treatment,the scores of PF,MH,V,BP and GH of group C and group D were higher compared with group A and group B,and the difference was statistically significant(P＜0.05).After treatment,the T1/2 and gastric residue rate within 120 min of the four groups were significantly decreased compared with those before treatment,and the difference was statistically significant(P＜0.05).Compared with patients in group A and group B after treatment,patients in group C and group D had shorter T1/2 and lower gastric residue rate within 120 min after treatment,and the difference was statistically significant(P＜0.05).The total effective rates of the four groups were 56.25%,62.50%,93.75%and 93.75%,respectively.Compared with group A and group B,the total effective rate of group C and group D was significantly higher,and the difference was statistically significant(P＜0.05).There was no significant difference in the total effective rate between group A and group B,group C and group D(P＞0.05).All patients in the four groups could persist to the end of treatment,and no obvious adverse reactions were observed.In clinical observation,there were no significant changes in blood and urine routine,stool routine,liver and kidney function,blood biochemistry and electrocardiogram before and after treatment.Conclusion The treatment of TEAS combined with Junzi Xiaopi Decoction for DGP can significantly improve the quality of life,gastric emptying function and treatment effect,which is better than that of TEAS or Junzi Xiaopi Decoction treating alone.
万方数据
维普
