Study on correlation between umbilical blood annexin A7 level and brain injury in mothers with gestational diabetes mellitus
Objective To analyze the correlation between umbilical blood annexin A7 level and brain injury in mothers with gestational diabetes mellitus.Methods 60 neonates of mothers with gestational diabetes mellitus were selected as the study group,and 60 neonates of mothers with normal blood glucose during pregnancy were selected as the control group.Umbilical blood was extracted from both groups,and the level of umbilical blood annexin A7 was detected by enzyme-linked immunosorbent assay(ELISA).After 3 d,the neonatal neurobehavior was evaluated by 20-item Neonatal Behavioral Neurological Assessment(NBNA).The umbilical blood annexin A7 level,NBNA score and incidence of brain injury were compared between the two groups,and the correlation between umbilical blood annexin A7 level and NBNA score was analyzed by Pearson correlation analysis.Results The umbilical blood annexin A7 of(27.24±3.18)μg/L in the study group was higher than(22.95±2.69)μg/L in the control group,the NBNA score of(36.34±1.27)points was lower than(38.25±1.56)points in the control group,and the incidence of brain injury of 13.33%was higher than 1.67%in the control group(P＜0.05).Pearson correlation analysis showed that there was a negative correlation between umbilical blood annexin A7 level and NBNA score(r=-0.613,P＜0.05).Conclusion There is a certain correlation between the level of umbilical blood annexin A7 and brain injury in mothers with gestational diabetes mellitus,and the level of umbilical blood annexin A7 can be used as a reference index to predict neonatal brain injury.
Mothers with gestational diabetes mellitusNeonatesUmbilical bloodAnnexin A7 levelsBrain injuryCorrelation
万方数据
维普
