Application effect analysis of allergen-specific IgE antibody detection in diagnosis of children with respiratory tract allergic diseases
Objective To investigate the positive distribution characteristics of serum allergen-specific immunoglobulin E(sIgE)antibody in children with respiratory tract allergic diseases,so as to provide a basis for clinical diagnosis and treatment.Methods The expression of allergen sIgE in 200 children with respiratory tract allergic diseases was by retrospectively analyzed,and the total serum IgE-positive rate,positive rate of allergen sIgE and positive tate of sIgE for different types of allergens were observed.Results Among 200 children with respiratory tract allergic diseases,the total IgE-positive rate was 68.50%(137/200),and the positive rate of male and female children were 68.52%and 68.48%,respectively.There was no significant difference in the total IgE-positive rate between male and female children(P＞0.05).The IgE-positive rates were 67.62%,69.56%and 69.23%in children aged 0-3 years,4-6 years and 7-12 years,and there was no significant difference in the total IgE-positive rates among different age groups(P＞0.05).The positive rates of allergic rhinitis,chronic cough,bronchitis,pneumonia and asthma were 68.18%,71.43%,66.67%,73.33%and 68.14%,respectively.There was no significant difference in total IgE-positive rate among children with different types of disease(P＞0.05).The sIgE-positive rate in 200 children was 62.50%(125/200).Among the 125 sIgE-positive children,the positive rate of inhalant allergen sIgE was 35.50%(71/200),the positive rate of food allergen sIgE was 11.00%(22/200),and the positive rate of both inhalant and food allergen sIgE was 16.00%(32/200).The sIgE positive rate of different allergens was significantly different(P＜0.05).Among the allergen sIgE-positive patients,the number of male and female children were 67 and 58 cases,respectively,and the positive rate were 62.04%and 63.04%,respectively.There was no significant difference in allergen sIgE-positive rate between male and female children(P＞0.05).The inhalant allergens in sIgE-positive children was ranked(from highest to lowest)as follows:dust mite(34.50%),household dust mite(25.50%),and Alternaria(18.00%).The food allergens in sIgE-positive children was ranked(from highest to lowest)as follows:egg white(13.00%),wheat(8.50%),peanut(6.50%),soybean(5.00%),crab(5.00%)from highest to lowest.Conclusion In children with respiratory tract allergic diseases,serum allergen sIgE antibody detection can provide information about allergen specificity,help guide clinical diagnosis and treatment,and play a significant role in disease diagnosis and treatment
Respiratory tract allergic diseasesAllergenSpecific immunoglobulin E
万方数据
维普
