Pharmacodynamic study on Ganmao Qingre tablets in preventing and treating H1N1 influenza A virus infection
Objective To investigate the pharmacodynamics of Ganmao Qingre tablets in the prevention and treatment of H1N1 influenza A virus infection.Methods A total of 108 patients with H1N1 influenza A virus infection were randomly divided into an observation group and a control group.The control group was treated with oseltamivir phosphate,and on the basis of this,the observation group was treated with Ganmao Qingre tablets.The clinical efficacy,symptom improvement indicators(onset time,antipyretic time,cough relieving time,recovery time),traditional Chinese medicine syndrome(fever,sore throat,headache,nasal congestion and nasal discharge,cough,fatigue)score,and serum inflammatory factors[C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]of the two groups were compared.Results The treatment effective rate of 96.30%in the observation group was significantly higher than 77.78%in the control group(P＜0.05).After treatment,the scores of fever,sore throat,headache,nasal congestion and nasal discharge,cough,and fatigue in the observation group were(0.83±0.24),(1.12±0.30),(1.07±0.29),(1.03±0.32),(1.05±0.33),and(1.09±0.28)points,which were significantly lower than(1.46±0.37).(2.31±0.58),(2.14±0.52),(2.25±0.63),(2.36±0.61),and(2.42±0.65)points in the control group(P＜0.05).The onset time,antipyretic time,cough relieving time and recovery time in the observation group were(1.03±0.34),(1.56±0.40),(4.35±0.68)and(6.63±1.26)d,which were shorter than(2.32±0.57),(2.63±0.74),(7.24±1.16)and(9.38±1.72)d in the control group(P＜0.05).After treatment,the levels of CRP of(2.11±0.56)mg/L,TNF-α of(19.34±2.20)μg/L and IL-6 of(4.02±0.54)ng/L in the observation group were lower than(4.83±0.69)mg/L,(25.89±2.73)μg/L and(6.13±0.62)ng/L in the control group(P＜0.05).Conclusion Ganmao Qingre Tablets has significant effect on the prevention and treatment of influenza A virus infection,in that it can effectively alleviate the syndromes,speed up the relief of symptoms and improve the anti-inflammatory effect.
H1N1 influenza A virus infectionGanmao Qingre tabletsOseltamivir phosphatePharmacodynamics
万方数据
维普
