Pathogenic analysis of respiratory tract infections in children in eastern Guangdong from 2019 to 2022
Objective To analyze the pathogenic distribution of respiratory tract infections in children in eastern Guangdong from 2019 to 2022,and provide reference for clinical diagnosis and treatment.Methods 3052 pharyngeal swab samples(all from children with acute respiratory infections who were treated at Shantou Central Hospital)were collected from May 2019 to October 2022.Pathogen nucleic acid was extracted and amplified by reverse transcription-polymerase chain reaction(RT-PCR)and multiple polymerase chain reaction(PCR)techniques.15 common respiratory pathogens were screened and divided into simple DNA virus group,simple RNA virus group,simple bacteria group,simple Mycoplasma pneumoniae group,mixed DNA and RNA virus group,mixed virus and bacteria group,mixed Mycoplasma pneumoniae and virus or bacteria group.The results of etiological detection of respiratory tract infection in children and the gender composition of each group were analyzed,and the positive detection of respiratory tract pathogens in children of different ages and the monthly distribution were compared.Results 3052 throat swab specimens were collected from children with respiratory tract infections,of which 2714 were positive and 338 were negative.There were statistically significant differences in the gender ratio,age distribution,disease type,monthly distribution,and body temperature between children with positive respiratory infections and those with negative respiratory infections(P＜0.05).Among 2714 children with respiratory tract infection,759 cases had the highest detection rate of cytomegalovirus,with a detection rate of 28.0%.Among 2714 children with respiratory tract infection,there were 1643 males(60.5%)and 1071 females(39.5%).The incidence rate of the same pathogen in males was significantly higher than that in females.The incidence rate of simple Mycoplasma pneumonia infection gradually increased with age.The incidence rate of simple DNA virus,simple RNA virus,simple bacteria,mixed DNA and RNA virus,mixed virus and bacteria gradually decreased with age.The simple DNA virus group,the simple RNA virus group,the simple Mycoplasma pneumoniae group,the mixed DNA and RNA virus group,the mixed Mycoplasma pneumoniae and virus or bacteria group had the highest incidence rates from July to September,which were 45.3%,40.7%,46.9%,43.9%,and 47.4%,respectively;and the simple bacterial group,the mixed virus and bacteria group had the highest incidence rates from April to June,which were 29.3%,29.3%,respectively.Conclusion Acute respiratory infections in children in eastern Guangdong are mainly caused by cytomegalovirus.The incidence rate of males was higher than that of females.The incidence rate of Mycoplasma pneumoniae infection increased with age,while the incidence rate of DNA virus,RNA virus,bacteria,mixed DNA and RNA virus,mixed virus and bacteria decreased with age.Respiratory tract infections from July to September should first be alert to viral and Mycoplasma pneumoniae infections.If bacterial infections are considered to be present in respiratory infections from July to September,it is important to be alert to the possibility of mixed virus or Mycoplasma pneumoniae infections.
万方数据
维普
