Analysis of the clinical efficacy of probiotics plus quadruple therapy for Helicobacter pylori infection in a young population
Objective To analyze the therapeutic effect of probiotics combined with quadruple therapy on Helicobacter pylori infection in a young population.Methods 90 young patients with Helicobacter pylori infection were grouped into a control group and an observation group according to the order of outpatients visits,with 45 cases in each group.The control group used quadruple therapy,and the observation group used probiotics on the basis of the control group.The eradication rate of Helicobacter pylori,serum inflammatory factors,immune function,intestinal flora and pepsinogen levels were compared between the two groups.Results The eradication rate of Helicobacter pylori in the observation group was 91.11%(41/45),which was higher than 71.11%in the control group,and the difference between the two groups was significant(P<0.05).After medication,the levels of C-reactive protein,tumor necrosis factor-α and interleukin-6 in both groups were decreased;the C-reactive protein in the observation group was(6.24±1.36)mg/L,the tumor necrosis factor-α was(121.24±22.18)pg/ml,and the interleukin-6 was(5.54±1.12)pg/ml,which were lower than(9.32±1.16)mg/L,(178.21±20.56)pg/ml,and(8.16±1.27)pg/ml in the control group(P<0.05).After medication,the levels of CD4+,CD4+/CD8+ increased,and CD8+ decreased in both groups;the observation group had CD4+ of(48.32±2.78)%and CD4+/CD8+ of(1.56±0.15),which were higher than(46.21±3.54)%and(1.32±0.12)in the control group;and CD8+ of(33.18±1.68)%was lower than(35.78±1.56)%in the control group(P<0.05).After medication,the numbers of bifidobacterium and lactobacillus increased,while the numbers of enterococcus and enterobacter decreased in both groups;the numbers of bifidobacterium and lactobacillus were(9.60±0.72)and(9.78±0.56)CFU/g in the observation group,which were higher than(8.44±0.81)and(8.54±0.48)CFU/g in the control group;the numbers of enterococcus and enterobacter were(7.12±1.16)and(7.18±0.72)CFU/g in the observation group,which were lower than(8.44±1.18)and(8.24±1.12)CFU/g in the control group(P<0.05).After medication,the levels of pepsinogen Ⅰ and pepsinogen Ⅰ/Ⅱ were(112.21±1.72)μg/L and(11.15±0.74)in the observation group,which were higher than(88.56±1.78)μg/L and(6.78±0.73)in the control group;the pepsinogen Ⅱ of(10.06±2.32)μg/L was lower than(11.12±2.44)μg/L in the control group(P<0.05).Conclusion The combination of probiotics and quadruple therapy in young patients with Helicobacter pylori infection can effectively remove Helicobacter pylori,regulate inflammatory factors and intestinal flora,improve immune function,and have a regulatory effect on pepsinogen levels,which can be promoted.
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