Clinical effect analysis of nifedipine controlled release tablets combined with fosinopril sodium tablets in the treatment of diabetes mellitus complicated with hypertension
Objective To analyze the clinical effect of nifedipine controlled release tablets combined with fosinopril sodium tablets in the treatment of diabetes mellitus complicated with hypertension.Methods 100 diabetes mellitus patients with hypertension were randomly divided into an observation group and a control group,with 50 cases in each group.The control group was treated with nifedipine controlled release tablets,and the observation group was treated with nifedipine controlled release tablets and fosinopril sodium tablets.Comparison was made on systolic blood pressure(SBP),diastolic blood pressure(DBP),renal function indicators[cystatin C(CysC),homocysteine(Hcy),urinary albumin excretion rate(UAER),urinary microalbumin(mALB)]and thrombomodulin(TM),von Willefibrile factor(vWF),transforming growth factor-β1(TGF-β1)levels before and after treatment,and occurrence of adverse reactions between the two groups.Results After treatment,SBP and DBP levels in both groups were significantly lower than those before treatment;and SBP of(135.43±6.43)mm Hg(1 mm Hg=0.133 kPa)and DBP of(87.87±3.30)mm Hg in the observation group were significantly lower than(137.54±2.91)and(96.76±2.65)mm Hg in the control group(P<0.05).After treatment,the levels of CysC,Hcy,UAER and mALB in both groups were significantly lower than those before treatment;the observation group had CysC of(0.31±0.63)mg/L,Hcy of(6.14±0.34)μmol/L,UAER of(115.73±7.57)μg/min and mALB of(24.25±1.43)mg/L,which were significantly lower than(0.76±0.02)mg/L,(11.31±0.58)μmol/L,(127.38±5.49)μg/min and(35.36±0.81)mg/L in the control group(P<0.05).After treatment,the levels of TM,vWF and TGF-β1 in both groups were significantly lower than those before treatment;the observation group had TM of(27.32±0.99)mg/L,vWF of(115.37±6.11)%and TGF-β1 of(111.27±5.37)mg/ml,which were significantly lower than(39.43±1.26)mg/L,(132.43±5.39)%and(132.36±5.31)mg/ml in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group after treatment(P>0.05).Conclusion The combination of nifedipine controlled release tablets and fosinopril sodium tablets in the treatment of diabetes mellitus patients with hypertension has a significant effect,and the symptoms of hypertension and diabetes mellitus have been significantly improved after medication,and no significant adverse reactions have occurred,which is worthy of promotion.
万方数据
维普
