The impact of single-port thoracoscopic segmentectomy on treatment effect and long-term prognosis of elderly patients with stageⅠnon-small-cell lung cancer
Objective To explore the impact of single-port thoracoscopic segmentectomy on treatment effect and long-term prognosis of elderly patients with stageⅠnon-small-cell lung cancer.Methods 142 elderly patients with stageⅠnon-small cell lung cancer were randomly divided into segmentectomy group and lobectomy group,with 71 cases in each group.The patients in the segmentectomy group were treated with single-port thoracoscopic segmentectomy,and the patients in the lobectomy group were treated with single-port thoracoscopic lobectomy.The long-term survival(Kaplan-Meier method was used to calculate the 3-year disease-free survival rate,3-year overall survival rate and 3-year recurrence rate)of the two groups was compared,and the factors affecting the long-term prognosis of single-port thoracoscopic segmentectomy were analyzed.Results The patients were followed up until January 31,2022 or until death for 13-70 months.The median survival was 53 months in the lobectomy group and 55 months in the segmentectomy group.There was no significant difference in 3-year disease-free survival,3-year overall survival and 3-year recurrence rate between the two groups(P>0.05).Univariate analysis showed that there were significant differences in vascular infiltration,pathological tissue type,T stage and pathological stage between the two groups(P<0.05).There was no significant difference in gender,age,smoking history,longitudinal diameter and tumor location between the two groups(P>0.05).Cox multivariate regression analysis showed that:vascular infiltration[OR=1.788,95%CI=(1.059,3.017)],non-adenocarcinoma[OR=1.650,95%CI=(1.180,2.307)],high T stage[OR=2.713,95%CI=(1.014,7.256)],high pathological stage[OR=2.578,95%CI=(1.143,5.815)]were independent risk factors for the long-term prognosis of single-port thoracoscopic segmentectomy(P<0.05).Conclusion The long-term survival of elderly patients with stageⅠnon-small cell lung cancer treated by single-port thoracoscopic segmentectomy is comparable to that of single-pore thoracoscopic lobectomy.Vascular infiltration,non-adenocarcinoma,high T stage and high pathological stage are independent risk factors for long-term prognosis of single-pore thoracoscopic segmentectomy.
Single-port thoracoscopic segmentectomyStageⅠnon-small-cell lung cancer in the elderlyPrognosisRisk factors
万方数据
维普
