Analysis of risk factors for hypofibrinogenemia in patients with severe infection caused by tigecycline
Objective To analyze the related risk factors for hypofibrinogenemia in patients with severe infection caused by tigecycline.Methods 101 patients with severe infection in intensive care unit who received tigecycline treatment were selected.The patients were divided into low FIB group[with hypofibrinogenemia,fibrinogen(FIB)<2.0 g/L,43 cases]and control group(without hypofibrinogenemia,FIB≥2.0 g/L,58 cases)according to whether they had hypofibrinogenemia or not.The clinical data were collected and the risk factors of tigecycline-induced hypofibrinogenemia and the change of FIB level after tigacycline was discontinued were analyzed.Results Univariate analysis showed that abdominal infection accounted for 41.86%in low FIB group and maintenance dose of 100 mg q.12 h.accounted for 30.23%,which were higher than 10.34%and 12.07%in the control group;the level of FIB before tigecycline was(3.71±1.27)g/L,which was lower than(4.65±1.49)g/L in the control group;the tigecycline treatment time was(8.98±2.47)d,which was longer than(7.33±2.33)d in the control group(P<0.05).There was no significant difference between the two groups in terms of age,sex,underlying diseases,previous surgical history,sequential organ failure assessment(SOFA)score before tigecycline treatment,acute physiology and chronic health evaluationⅡ(APACHEⅡ)score before tigecycline treatment,pathogenic bacteria,organ function before tigecycline treatment,proportion of load dose 100 mg and combined use of cefoperazone and sulbactam sodium(P>0.05).Multivariate analysis showed that the main risk factors of tigacycline induced hypofibrinogenemia were abdominal infection and low FIB level before tigecycline treatment(P<0.05).In the low FIB group,there were 24 patients who stopped tigecycline,among which 19 patients recovered to normal level after stopping tigecycline,the proportion was 79.17%,and the recovery time was(5.52±2.06)d.Conclusion The risk factors of hypofibrinogenemia in patients with severe infection caused by tigecycline are abdominal infection and low FIB level before tigecycline treatment.In clinical treatment,it is necessary to prevent abdominal infection,shorten the medication time as much as possible,and pay attention to monitoring the FIB level of patients.
万方数据
维普
