Objective To analyze the application effect of two detection methods of syphilis antibody in early diagnosis of syphilis.Methods 117 cases were selected from the patients with positive syphilis spirochete gelatin particle agglutination test,and 113 healthy subjects were selected.All the study subjects were examined by syphilis spirochete gelatin particle agglutination test and toluidine red unheated serum test,and the results of syphilis spirochete gelatin particle agglutination test were used as the gold standard to analyze the results of the toluidine red unheated serum test as well as the sensitivity and specificity of diagnosis.Results The syphilis spirochete gelatin particle agglutination test detected 117 positive cases and 113 negative cases.Using the results of syphilis spirochete gelatin particle agglutination test as the gold standard,toluidine red unheated serum test detected 99 positive patients,accounting for 43.04%,and 131 negative patients,accounting for 56.96%,with a diagnostic sensitivity and specificity of 84.62%(99/117)and 100.00%(113/113),respectively.Conclusion Syphilis is highly contagious and harmful to the body,so it needs to be screened and treated as early as possible to avoid delayed treatment.Syphilis spirochete gelatin particle agglutination test is more sensitive,which can improve the quality of diagnosis and reduce misdiagnosis,but the test is more expensive and more complicated to operate.Therefore,toluidine red unheated serum test can be used for screening in the actual detection process,and the combination of the two detection methods has a better effect.
关键词
梅毒/抗体检测/早期诊断/梅毒螺旋体明胶颗粒凝集试验/甲苯胺红不加热血清试验
Key words
Syphilis/Antibody testing/Early diagnosis/Treponema pallidum particle agglutination assay/Toluidine red unheated serum test
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