Effect of fiberoptic bronchoscopic lavage combined with high-dose ambroxol hydrochloride on inflammatory factors in elderly patients with severe pneumonia
Objective To explore the effect of fiberoptic bronchoscopic lavage combined with high-dose ambroxol hydrochloride on inflammatory factors in elderly patients with severe pneumonia.Methods 108 elderly patients with severe pneumonia were divided into group A and group B by random number table method,each with 54 cases.Both groups received conventional treatment.Group A received conventional dose of ambroxol hydrochloride treatment,and group B received fiberoptic bronchoscopic lavage combined with high-dose ambroxol hydrochloride treatment.Comparison was made on clinical efficacy,blood gas analysis indicators[arterial oxygen saturation(SaO2),arterial partial pressure of oxygen(PaO2),and oxygenation index(PaO2/FiO2)],inflammatory factors[C-reactive protein(CRP),white blood cell count(WBC),procalcitonin(PCT),neutrophil percentage(NEUT%)],Acute Physiology and chronic Healthy EvaluationⅡ(APACHE Ⅱ)score,ventilator supporting time between the two groups.Results The total effective rates of group B and group A after 14 d of treatment were 96.30%and 79.63%,respectively.Compared with group A,group B had a higher total effective rate(P<0.05).After 14 d of treatment,SaO2,PaO2 and PaO2/FiO2 levels in both groups were higher than those before treatment;and PaO2/FiO2 of(314.53±33.58)mm Hg(1 mm Hg=0.133 kPa)in group B was higher than(267.48±31.71)mm Hg in group A(P<0.05).After 14 d of treatment,the levels of serum CRP,WBC,PCT and NEUT%were all lower than those before treatment;group B had CRP of(14.76±2.42)mg/L,WBC of(6.75±1.02)×109/L,PCT of(0.13±0.04)ng/L and NEUT%of(49.45±3.36)%,which were lower than(18.65±3.34)mg/L,(10.32±1.21)×109/L,(0.41±0.11)ng/L and(56.25±4.37)%in group A(P<0.05).After 14 d of treatment,the APACHE Ⅱ score in both groups was lower than that before treatment,and the APACHE Ⅱscore of(10.43±1.01)points in group B was lower than(15.75±3.76)points in group A(P<0.05).The ventilator supporting time of(6.54±0.76)d in group B was shorter than(12.65±0.32)d in group A(P<0.05).Conclusion Fiberoptic bronchoscopic lavage combined with high-dose ambroxol hydrochloride can control the development of severe pneumonia in elderly patients,shorten the ventilator supporting time,improve the blood gas indicators of patients,and reduce the inflammatory response,so as to improve the clinical efficacy.
Severe pneumoniaOld ageFiberoptic bronchoscopic lavageAmbroxol hydrochlorideInflammatory factor
万方数据
维普
